First let us understand why MSMQ came in to picture and then rest will follow. Let us take a scenario where your client needs to upload data to a central server. If everything will works fine and the server is available 24 hours to client then there are no issues. In case the server is not available, the clients will fail and the data will not be delivered. There is where MSMQ comes in to picture. It eliminates the need of persistent connection to a server. Therefore, what you do is deploy a MSMQ server and let the clients post message to this MSMQ server. When your actual server runs, it just picks up the message from the queue. In short, neither the client nor the server needs to be up and running on the same time. In WCF we have a client and service model and in real world it is very much practical possible that both the entities will not be available at one time.