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Where the Node.js is an entity that runs in a virtual environment, using JavaScript as the primary scripting language. That's uses a simple V8 environment to run on, which helps in the provision of features like the non-blocking I/O and a single-threaded event loop.
Where Node.js is a very powerful JavaScript, it is based platform or framework which is built on Google Chrome’s JavaScript V8 Engine. It runtime allows executing the JavaScript code on any machine outside a browser.
Node.js is a Server side scripting which is used to build scalable programs. Its multiple advantages over other server side languages, the prominent being non-blocking I/O.